It is resistant to most beta-lactamases of Gram-positive and Gram-negative organisms, penicillinase stafillokokov, Clostridium difficile. Applied cefotaxime for masteron cycle infections caused by microorganisms sensitive to it (mainly Gram): infections of the respiratory and urinary tract infections, kidney; ear infections, throat, nose, septicemia, endocarditis, meningitis; infections of the bones and soft tissues of the abdominal cavity; in infectious and inflammatory diseases of the pelvic organs, gonorrhea; wound and burn infections and others.
Contraindications The drug is contraindicated in case of hypersensitivity to cephalosporin antibiotics. Possible cross-allergy between penicillins, cephalosporins, carbapenems.
Caution is needed when administering the drug to patients with impaired renal function and liver, ulcerative colitis, newborn.
Children up to 2,5 years can not be used intramuscular injection of the drug.
Pregnancy and lactation Use of the drug during pregnancy is possible only when the intended benefits masteron only cycle to the mother outweighs the potential risk to the fetus.
Cefotaxime is excreted in breast milk, so breast-feeding should be discontinued, if necessary, the appointment during lactation.
Dosage and administration Apply cefotaxime intramuscularly and intravenously. For intramuscular injections of 0.5 g was dissolved in 2 ml (or 1 g in 4 ml) of sterile water for injection. injected deep into the masteron cycle gluteal muscle. As the solvent, when administered intramuscularly also used 1% lidocaine (0.5 g – 2 mL per 1 g – 4 mL).
For intravenous administration of 0.5 g -1 cefotaxime was dissolved in 10 ml of sterile water for injection. Enter slowly for 3-5 minutes.
For drip (for 50-60 minutes) is dissolved 2 g in 100 ml of isotonic sodium chloride solution or 5% glucose solution.
The usual dose of cefotaxime for adults and children over 12 years – 1 g every 12 hours. In severe cases, the dose was increased to 3 or 4 grams per day, the drug is administered 3 or 4 times in 1 year
The maximum daily dose, depending on the severity of the disease, can be increased to 12 g.
The usual dose for infants and children younger than 12 years – 50-100 mg / kg body weight per day of administration at intervals of 6 to 12 hours. For premature children the daily dosage should not exceed 50 mg / kg.
In the case of renal function reduce the dose masteron cycle. If creatinine clearance of 10 ml / min or less daily dose halved.
Side effects : Allergic reactions: urticaria, chills or fever, rash, pruritus, rarely – bronchospasm, eosinophilia, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), angioedema, anaphylactic shock.
From the digestive system: nausea, vomiting, diarrhea or constipation, bloating, abdominal pain, goiter, liver dysfunction (increased activity of “liver” transaminases, alkaline phosphatase, hypercreatininemia, hyperbilirubinemia), rarely – stomatitis, glossitis, pseudomembranous enterocolitis.
From the side of hematopoiesis: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia, anticoagulation.
From the urinary system: renal dysfunction (azotemia, increased urea in the blood, oliguria, anuria).
From the nervous system: headache, dizziness.
Local reactions: phlebitis, pain along the vein, pain and infiltration in the ground / m introduction.
Other: superinfection (including candidiasis vaginitis).
Overdose symptoms: seizures, encephalopathy (in the case of high doses, especially in patients with renal insufficiency), tremor, increased neuromuscular excitability. Treatment: symptomatic therapy.
Interaction with other drugs With simultaneous use of cefotaxime with potentially nephrotoxic drugs (aminoglycosides, furosemide) need to monitor renal function (risk of nephrotoxicity of the latter).
Solutions cefotaxime incompatible with solutions of other antibiotics in the same syringe or dropper.
Cautions In the first weeks of treatment may be pseudomembranous colitis manifested by severe prolonged diarrhea. In this case stop taking the drug and prescribe appropriate therapy masteron, including vancomycin or metronidazole.
Before the appointment of the drug should be collected allergic history, especially with regard to beta-lactam antibiotics. Known cross-allergy between penicillins and cephalosporins. In persons with a history there are indications of an allergic reaction to penicillin, the drug masteron propionate dosage is used with extreme caution.
In the event of hypersensitivity reactions (which are severe and even lead to death) drug overturned.
When the duration of drug treatment over 10 days need to be monitored picture peripheral blood.
Perhaps the discovery of false positive Coombs test.
When determining glucose in urine nonenzymatic method (for example, by Benedict) false-positive masteron cycle results are possible.
Product form 0.25 g, 0.5 g and 1.0 g in a glass bottle, 1 bottle in a cardboard box with the instructions for medical use.
Storage conditions List B. The temperature is not above 25 ° C, protected from light. Keep out of the reach of children.