It has masteron only cycle a bacteriostatic action. -ingibirovanie Mechanism of action of protein synthesis in bacteria cell by binding to the 30S subunit of the bacterial ribosome, resulting in a breach of stability and osmotic lysis of microbial cells.Kirin is rapidly absorbed when administered intramuscularly. Iradikatsiya microorganisms assessed by the absence of crop growth after 96 hours.Kirin is indicated for the treatment of urogenital gonorrhea in men and women.
Increased sensitivity to spectinomycin; Children up to age 3 years.
Pregnancy and lactation
Controlled studies in pregnant women have been conducted. At the standard dose for adults spectinomycin has been used successfully for the treatment of gonorrhea in pregnant women, especially if you are allergic to penicillins or pathogen stability. Kirin should be used during pregnancy in cases where the potential benefit to women than the potential harm to the fetus.
There is insufficient data on the use of the drug in nursing mothers. At the time of treatment Kirin breast-feeding should be discontinued.
Dosage and administration:
To prepare the suspension to the contents of the vial add 3.2 ml of water for injection with benzyl alcohol 0.9%. Immediately stir. Each vial provides a 5 ml suspension containing 400 mg / ml spectinomycin.The suspension should be used immediately after preparation, unspent suspension must not be stored. Suspensions used for administration with a needle of 0.8 mm diameter and 40 mm in length.
Adults: one dose of 2 g (5 ml) for deep intramuscular injection. Injection should be made ??deep in the upper outer quadrant of the gluteus maximus. The dose may be split into two administration. In severe cases, the dose may be increased to 4 g (10 ml).
Elderly patients: The usual dose for adults. There is no evidence to suggest the worst tolerated by elderly patients.
Children: children over 3 years old with a body weight up to 45 kg of the drug is administered at a dose of 40 mg / kg body weight, and children weighing more than 45 kg – 2.0 g / m once.
Side effects: Usually Kirin well tolerated.
There are: Allergic reactions: sometimes itchy erythematous blotchy rash, hives, fever, chills, very rarely – anaphylactic shock. On the part of the central nervous system: rarely dizziness, insomnia. From the digestive system: nausea. With liver: very rare hepatotoxicity, cholestatic jaundice. on the part of the kidney: in some cases – decreased urine output, hematuria. Irritant effect on the fabric: . seal and soreness at the injection site (less than 1% of patients) Other: occasionally marked masteron only cycle decrease in creatinine clearance , hematocrit, hemoglobin, elevated alkaline phosphatase, urea, and gamma-glutamyl transferase in the serum.
Drug Interactions: Spectinomycin reduces excretion of lithium, which requires a dose reduction lithium drugs.
In patients with depressed renal function while removing substantially increased. When disposable regimen is not considered as a contraindication, but use should be limited to cases where other treatments ineffective.
Kirin should not be administered 24 hours prior to dialysis, since efficacy of the drug can be reduced by reducing the concentration of drug in the serum. Dialysis results in a 50% reduction in plasma level of spectinomycin.
Treatment of gonorrhea with antibiotics in high doses, can mask the incubation period for syphilis. Therefore, patients undergoing antigonoreynaya therapy should be observed within 4-6 weeks. If there is a suspicion for syphilis serology testing should be carried out for at least 4 months.
. Infants and children up to 3 years old should not be administered the drug, made ??on the basis of the applied solvent – water for injections with benzyl alcohol, in view of the fact that benzyl alcohol can cause neurological and other complications.
Powder for suspension for intramuscular injection of 2 g to 2 g of spectinomycin in a glass bottle (type II), a sealed rubber stopper, aluminum cap rolled up.
At 3.2 ml solvent – water for injection with benzyl alcohol 0.9% in a sealed glass ampoule (I type) masteron only cycle with a dark band on the neck fracture ampoules.
1 vial and 1 ampoule together with instructions for use placed in a cardboard box with cardboard divider.
Store at 15 ° C -. 30 ° C
Keep out of the reach of children.
Do not use after the expiration date.